The Lonesome Dove quartet follows Augustus McCrae and Woodrow Call from their first service as young Texas Rangers to old age at the closing of the nineteenth-century frontier. Dead Man’s Walk and Comanche Moon trace their early experiences during the Republic of Texas, the Santa Fe expedition and the long conflict between Texan expansion and Comanche power.
Lonesome Dove and Streets of Laredo move into the cattle-drive era and its decline, using the friendship between Gus and Call to examine loyalty, leadership, violence and loss. Publication order differs from story chronology: Lonesome Dove and Streets of Laredo were published first, followed by the two prequels.